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What is leaky gut

doi:10.1089/ARS.2009.2695

In detail, IL-4 binds with its receptor to activate JAK2 downstream, inducing STAT6 phosphorylation and entering the nucleus to bind to promoter elements of IL-4-responsive gene, thus transcribing M2 lineage genes (e.g., Il10 , Arg-1 ) to drive M2 differentiation, which acts as a vital immunoregulator to block inflammatory process [255,256,257]

Another source of deficiency can be malabsorption issues, where the body is unable to properly absorb B12 from the intestines due to various gastrointestinal disorders